Amyloid clearance by monocytes correlates with AD progression, page-9

Thanks Pivalde very interesting.

I've previously researched granulocyte colony-stimulating factor (G-CSF) therapy, so your posts got me thinking if recruiting more white blood cells out of marrow could help with the amyloid clearance they describe.

I found this 2011 paper testing G-CSF and Stem Cell Factor to AD mice and found that this recruits more microglial cells (macrophages, i.e a monocyte) to the brain from marrow, leading to greater clearance of the amyloid.
https://alzres.biomedcentral.com/articles/10.1186/alzrt67#:~:text=In%20addition%20to%20the%20acute,and%20G%2DCSF%20in%20AD.

Also this 2021 paper of a phase 2 study of Granulocyte-macrophage colony-stimulating factor (GM-CSF) on AD patients shows it leads to normalization of amyloid and tau, plus they saw cognition improvements! You may already be across this paper, but quite interesting.
https://alz-journals.onlinelibrary.wiley.com/doi/full/10.1002/trc2.12158

PBT2 is before my time and I don't know too much about it, but from your comments on it breaking amyloid-Zn complex apart in order to load the amyloid on the monocytes - perhaps as well as trying to give monocytes more energy they could also think about recruiting many more monocytes to brain using GM-CSF, or similar, at same time as PBT2 to have greater clearance effect.

Cheers