Not sure if this topic has been discussed already. I didn't see...

Not sure if this topic has been discussed already. I didn't see anything...

I had a read through of the JAMA paper on the weekend to see what the fuss was about. This caught my attention:

"Of 7486 patients not receiving testosterone therapy, 681 died, 420 had MIs, and 486 had
strokes. Among 1223 patients receiving testosterone therapy, 67 died, 23 had MIs, and 33 had
strokes."

So, that's:
21% total events for patients not receiving therapy
10% total events for patients who are receiving therapy

That certainly doesn't look like an increased risk. It looks like the opposite.

I quizzed a senior MD on this who, after taking a superficial look at the paper (I emphasise superficial because I don't want to give anyone the impression that it was a detailed review or any kind of medical opinion), advised that the group undergoing therapy appeared to be healthier to begin with than the group that wasn't. The author had used weightings to "normalise" the groups. The weightings may have overcompensated.

Are there any subject matter experts on here with an opinion?