@JohnI will respond one more time but please accept that 'time' is my issue (clearly not yours), so I can't play HC tennis (serve - return - serve ... ) with you.
You comment ...
"
While I appreciate your response, you're effectively saying that you're comfortable with how IMU is progressing PD1-VAXX because of what a now ex-employee has told you ..."
1. No, not really. The trial start has been a little slower than I expected ... but remember, the timeline is now in the hands of the 'sponsor', not IMU.
2. I am capable of grasping that IMU have de-prioritised PD1-VAXX to concentrate on other programs. Clearly they are very happy for neo-POLEM to be proceeding with the sponsor.
3. Actually, I'm not that excited about many aspects of IMU's program management, but I can see I'm not the only one.
4. "a now ex-employee has told me" implies what? (Don't bother answering, I actually don't need you to). When I was corresponding with Nic he was still an employee, and a much valued one and a very credible source of information.
5. "
a generally higher response rate" doesn't confirm it 'across the board'. Believe it or not, there are indications where the FDA will not support the use of Keytruda. I can supply evidence but I expect you already know this.
6. You make a comparison of Keytruda with PD1-Vaxx in the treatment of NSCLC !!! Do we have any data that will allow us to compare PD1-Vaxx vs Keytruda in mismatch repair-deficient /microsatellite instability high (dMMR/MSI-high) colorectal cancer ? I suspect not but I'm happy to see the evidence.
7. Yes, I too would like to know the final dosing in the neo-POLEM trials ... but I can wait, I'm sure we will hear soon enough.
8. I am not looking to offend but you have now used up your quota of my time. OaO.
@dingoI don't know where Nic is working now. He was going to take a break and concentrate on his sailing (perhaps Slick knows).
On a similar matter, I used to correspond with Paul W fairly regularly but I have not heard from him since he stood down from his position. If I hear I will be happy to let you know.
As always, the opinions of one poster.
(20min delay)