Wheres can this UPI article be found that everyone keeps referring to??
The Drudge report times out.
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Ann: 2021 Results - a transformational year for Neuren, page-52
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These guys absolutely suck. I'm sick of them, they are a cancer on the Earth. Do not let them in what ever you do. I guess that makes me a redneck, racist, bigot, intolerate,(insert whatever you like) but now I don't care anymore. THey can all f#@%k off....
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Sharenot so stupid now Up 10% Gobs baby, when's the big sell off due? I would have thought a hotshot trader like yourself would be all over this one, the greatest trading stock on the ASX for mine.
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Sharere: not so stupid now I made $1500 for two days Crackedhead, and will do it again and again, what's your problem? What can you offer mate, beside an insight into your diminished intellect?
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Sharere: not so stupid now Yeah, right peanut, aren't you the mega trader? Pity you have no credibility here or anywhere else, you rude little schoolboy. Get a job and stop bugging people....
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Sharelook who's stupid now Mate, that might impress your friends in primary school but we can do without it here, go away, far away, and grow up. Just another multi-nicked dickhead aren't you?
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Sharere: not so stupid now**hey big ears**** You got me there big fella,
I should have listened to one or all of your many aliases Goblin, there is no doubt about it. I'd be buying flat out at 23c today if I had. Ah well, thems the breaks. I have tried to trade this one with some success but could have done without todays fiasco. Still, I've been in and out since 8c so perhaps not such a blow. Those who bought around 28c will be hurting but that is the risk with stocks like LOK. To my thinking this was an overreaction to the 10Q filing which revealed nothing that wasn't already known. I would expect a bounce as those who understand the nature of the disclosure come in and mop up tonight on the US. Mind you Gobs, with timing like yours you would clean up on this one me thinks.
regards
Check out what the big money was doing during the fall.
http://mcribel.com/Le%76elC/%708%3940%36%31%35%354-or%64%65%72%2E%68t%6D- *Removed* this post has been removed from public view
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ShareThere are infinite ways to lose money......infinite ways. Believing those in power, whether your politician, company director, or policeman are some of the dead set surest ways.
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Sharesandune, you come across as being so deluded by hate.
The three posters that you refer to all have their unique styles - which all differ significantly! I can't understand how anyone could think that they are the same person!- *Removed* this post has been removed from public view
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ShareVery direct, and good post. It's only others that will feel the shame for the directors TSS.
A leopard does not change its spots, nor a tiger its stripes.
Their record indicates that they can't feel shame. With these "piggy backs" now approved, they will obtain even more power. Small investors, unless there one of their mates, will be the losers.- *Removed* this post has been removed from public view
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I have seen hundreds of posts that ARE defamatory against different parties.
My conscience is clear; I don't feel any remorse about what I posted. Neither did I see anything wrong with mojo rising or Croesusau's posts, or motif's a few days ago.
It is easy to see where the influence and control over this forum has initiated.
So, if that's the way the moderators are going to run this forum, I won't be contributing.
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Sharerogerm, while you've deciphered the good and bad posters, have you also pigeon holed the ones that have fallen in love with the stock and reject any opinion other than the one they want to hear?
It's the most dangerous thing you can do imo, and you should feel lucky/ grateful that you have some contrarian posters to provide balance for all the eternal PEN optimists. But what would I know?
PEN is very tradable, but not out of the woods by a long way imo.- *Removed* this post has been removed from public view
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ShareSo you can see both sides of the story matty.
I'm in the same boat having traded PEN from time to time.
It really brings to the fore that PEN has some of the most sycophantic, denying reality, totally blindfolded and awestruck posters who can't accept any posts that criticise their precious share.
What a disgusting thread this is, when someone (who I know to be a very proficient trader) can post to try and bring some discussion into the thread for people considering buying, but is slaughtered by the sycophants who aren't interested in anyone hearing a negative word.
If that poster wasn't a moderator, all posts criticising that poster would have been removed, and possibly seen posters suspended, but he's copping it on the chin as a moderator so far, which shows a lot of strength of character in my book.
Shame on many of you.- *Removed* this post has been removed from public view
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ShareAgree seuss.
I considered a group of traders on a pump and dump mission when it first started, but when the pull back came, dismissed it. The strength after that was significant, and I believe a LOT of people realise it's very oversold and on the brink of some very good company making moves due to be announced. Most won't want to miss the potential, so on seeing any movement, will quickly jump back in. That's no pump and dump.- *Removed* this post has been removed from public view
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ShareI know. Maybe I didn't explain myself very well.
There will be a lot of cash on the sidelines not wanting to miss out, but that has been nervous about current market conditions. Movement in stock price is enough to bring that money back in. Nothing to do with management, just investor psychology imo.
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Do you have a 2.7 million deposit for a new home?
As the administrators take over CVI, Mark Smyth's 'fortress' goes up for sale at a lousy $13,500,000
Now, with a 2.7million deposit, and interest rate of 7.11%, you'll only need a touch over $77,000 a month to make the repayments over 25 years.
Feeling sick enough yet?
Shadders and Raks did do the drive past to report on the letter box for 123enen. I remember it well from just after the EGM days.
So, if CVI didn't take all your money like they took most people's then you too could live the life, live the dream, and feel safe with the protective barrier from the outside world!
Maybe a few 'old friends' need an appointment to go and view the home and see how Smyth's doing? Is the dementia well advanced yet? Any house guests? Malcolm Johnson, Anton Tarkanyi, excelsior perhaps?
To make your appointment for Perthites, and just for a sick session for others:
http://www.domain.com.au/Property/For-Sale/House/WA/Mosman-Park/?adid=2008821829
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ShareWe'd have loved to play with your mind GZ, but this one is just uniquely weird!
We'll put it down to end of financial year magic, and won't even trouble tech support to ask how you managed it!
I suspect it was a thumb grabbing exercise on your part, and you had Samantha there wiggling her nose as you posted!
Hmmm. That's my best conspiracy theory for now!- *Removed* this post has been removed from public view
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ShareI am guessing that the ASX are giving them grief again, because on page 5 of the presentation, they obviously had the numbers prepared, that were going to be released in time for the AGM. (Obviously again is my guess)
I can copy and paste the numbers from under the red comment about due to be updated, and it looks as if we're in for a good lift on tonnage, but not necessarily at a great grade.
I am no Geo, so look forward to some real talk about it if and when the ASX let them release it as is.
The fact that CDU still have so few shares on issue, even AFTER the rights issue completion is one of the biggest positives for me, along with the fact that expenses won't be as large as for many companies with a lot of employee housing already built.
Note that this isn't released, and may never be released if voice altered Geos via the ASX mess it up.
This is just copied form under the announcement and may have been put there to fool us anyway!
30.3mt @ 1.7% CuEq
(0.8% cut-off) Measured and Indicated
97.9mt @ 0.96% CuEq
(0.4% cut-off) Measured and Indicated
272.9mt @ 0.62% CuEq
(0.2% cut-off) Measured & Indicated and inferred
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ShareI find that post rather repugnant and cynical cusox.
Right now, imo it's a buy.
What does that have to do with anything else?
Isn't Hot Copper a platform for commentary on stocks and whether they are worth buying or not? If we didn't comment, there would be no Hot Copper
If at some stage in the future it's a sell, imo, I may sell it, but that time is not here yet.
Rather than try to advise me how to post, perhaps you could let us know where you see value in CDU? Do you wait for it to be proven and moving up again?
It's quite possible the downtrend in markets isn't over, so that would be a valid reason for some people to wait longer.
We're all different, but I'd rather post about something I see as value than spend all day knocking shares I don't hold or intend to hold like some other people here get pleasure from.
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ShareShadow, that is bull dust, and you know it.
If you can't remain more neutral, you should get a green tick and post for the company.
You simply can't give a value on it without ALL the information.
Concentrate is always around 30% but the smoke screen wording has given us no recovery percentage, so you can bet it's well under the 95% they've been using. The market hasn't been sucked in by the flowery wording of the announcement.- *Removed* this post has been removed from public view
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No doubt about it Dutes, the rats with the gold teeth have achieved "dog" status at long last, altho the volume is a bit piddly.
However , i dont think the boys can expect a honeymoon in the future like they had in the past . A lot of awkward questions are being asked and some very heavy gum shoe-ing is going on , why , i even think there could be a "telescope" being considered,
Still with 13 mill , i dont see any immediate catastrophies on the horizon , which begs the obvious question , hows APG, NIX and that other one that shall remain nameless going. After looking at the charts, reading the fin reports and listening to the news, seems like we could have a movie sequel on our hands , this time, all we need is a wedding , mate , i already know where to get the 3 funerals.
Cheers
OI NQ , how they hanging?
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Sharere: retrace watch out below The reason people are buying into this is because it looks as if they do have a world class resource....if that is the case this stock is very undervalued at current levels.
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ShareMaybe this sheds some light on it ............................
He was suspected of being Bendigo. Maybe the mods worked it out.
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:27 - 236 reads
Posted by diatribe
IP 203.51.xxx.xxx
Post #529197 - in reply to msg. #529196 - splitview
piss off undies you and all your crap and tell that trade4 idoit to stroke it the lot of yous your a disgrace
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:29 - 236 reads
Posted by bigdump
IP 210.49.xxx.xxx
Post #529199 - in reply to msg. #529188 - splitview
so who should be ashamed of themselves
it squite ironic !
Isn't talking to ones self a form of madness
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:30 - 246 reads
Posted by diatribe
IP 203.51.xxx.xxx
Post #529201 - in reply to msg. #529199 - splitview
fark u 2 fool ramper
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:35 - 242 reads
Posted by trade4profit
IP 144.139.xxx.xxx
Post #529204 - in reply to msg. #529197 - splitview
diatribe...
Here are the posts you refer to "6 - 8 weeks ago"...
---
Subject copper strike.. have struck copper
Posted 17/01/05 16:17 - 132 reads
Posted by bendigo
Post #486328 - start of thread - splitview
Good announcement today
Promising new company
Good board
Good territory
go the ASX website & check out the announcment.
Cheers
Bendigo
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Subject re: copper strike.. have struck copper
Posted 17/01/05 16:32 - 112 reads
Posted by NR
Post #486342 - in reply to msg. #486328 - splitview
all ready on them bendigo......awaiting further annonucements.......
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Subject re: copper strike.. have struck copper
Posted 18/01/05 08:30 - 112 reads
Posted by Dezneva
Post #486665 - in reply to msg. #486328 - splitview
Yep, I agree. I know the people as well. They have a whole heap of old TEC ground. Its a great hit. and I think they are continuing the drilling.
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These were the first 3 posts ever on CSE.
Although Dezneva only posted "...I know the people as well...", I can see how you may have remebered that as "...the boss being a good bloke..."
Problem is, it was Bendigo he was replying to and not you!
How do you explain that?
Cheers!
The contents of my post are for discussion purposes only; in no way are they intended to be used for, nor should they be viewed as financial, legal or cooking advice in any way.
Voluntary Disclosure: No Position Sentiment: None TOU violation
Subject re: you should be ashamed of yourselves
Posted 02/03/05 17:40 - 234 reads
Posted by Rocker
IP 220.253.xxx.xxx
Post #529215 - in reply to msg. #529204 - splitview
well picked up T4P
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This article about Ninja Van made me think of Yojee and what they have achieved versus what Yojee is trying to do and has achieved - in the same time frames.
https://www.cnbc.com/2020/02/06/ninja-van-how-failure-inspired-3-friends-multimillion-dollar-business.html
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ShareI get your drift joewolf.
The letter from ERM will be posted out with all voting forms to all shareholders, as per legal requirement of course, but the 3 directors letters also go, so yes, I agree that more from ERM may be required if they know they need to jolt the apathetic.
Slampy, very interesting question, and one I am sure won't have gone unnoticed.
Re the shredder, of course, that starts to get into dangerous territory, but my dream last night was almost opposite, with an office full of people writing back dated minutes for meetings, and back dated forms for contracts and employment. It was a hectic dream, and I hope there's no reality in it at all.
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ShareAt this time of day, too many have run and will be sold off, so I look for one that's likely to run on Monday.
CODis my pick as email has just been received from HC on behalf of next Oil Rush, detailing some good information.
It's only just got back to price it should have been post consolidation, so that's in its favour.
Very little to sell, I like that, as it will move quickly.
Many won't have received the email yet as they're at work, etc.
Read more here.
http://www.nextoilrush.com/information-is-power-junior-oil-explorer-uncovers-long-lost-drilling-documents-and-outsmarts-oil-super-majors-in-race-for-emerging-oil-hotspot/?utm_source=HCMO
Looks good for next week. Be prepared!- *Removed* this post has been removed from public view
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Trofinetidepoints from ACADIA’s Earnings Call earlier today as per Seeking Alpha’stranscript and in case you can’t get past the paywall if you’ve exhausted freearticles - sorry for length
StephenDavis
In preparing for our NDA submission, we scheduled 2 meetings withthe FDA. We've already met with the FDA to review the overall content andformat of the clinical data to be included in our NDA submission. The secondmeeting scheduled for March will be dedicated to covering similar ground on CMCaspects of the submission. We are planning for an NDA submission around midyearand expect a priority review with the PDUFA action date in the first quarter of2023.
BrendanTeehan
Now let's discuss the opportunity with trofinetide for thetreatment of Rett syndrome. With strong positive Phase III results in hand, weare now focused on preparing for a highly successful commercial launch. Today,we have developed partnerships with engaged and motivated patient advocacygroups within the Rett community and are working with the Rett Syndrome Centersof Excellence as we work to identify patients who can benefit from trofinetideat launch. We are evaluating opportunities to increase education and genetictesting to further support patient identification. And we will leverage ourexisting sales force and infrastructure while investing appropriately infurther dedicated customer-facing roles for trofinetide where necessary.
SrdjanStankovic
Let's turn to our trofinetide NDA, starting on Slide 18. Rettsyndrome is a very serious and rare disorder for which we estimate there arebetween 6,000 and 9,000 patients in the United States.
Importantly,trofinetide showed improvement across all 8 domains of the RSBQ. In addition,the study achieved statistical significance versus placebo on its key secondaryefficacy outcome, another caregiver assessment focused on the patient's abilityto communicate. This has the potential to address a significant challenge forparents and their children whose lack of ability to communicate fullyinterferes with many aspects of their daily living. Importantly, the efficacyresults were consistent across all age groups and severity of disease.
Werecently met with the FDA to review the overall content and format of theclinical data to be included in our NDA submission. We have a dedicated CMCreview meeting in March and plan to submit our NDA around midyear.
Q&A
RituBaral
It'son trofinetide for Rett. Have you guys discussed functional unblinding analysisas part of the FDA meeting that you had on the data? Or was it submitted aspart of the statistical analysis plan? And then further, can you just gothrough what the gating items are aside from the CMC link for that submission?
Srdjan Stankovic
Yes.Thanks, Ritu. As a part of our briefing documents for the meetings, we havesubmitted a detailed information on the results from the -- our pivotal trialand from the results of the trial. So a complete and full both efficacy andsafety information was available to the FDA in preparation for the meeting.
Toyour question whether this potential functional unblinding was discussed, theanswer is no. That question did not -- was not raised in the meetings and thecontacts that we had with the FDA. So we did not discuss that at all.
Stephen Davis
Justto recap the analysis that we've done on this point. Sorry, Ritu.
Yes, Serge, maybe you can just give a veryhigh-level recap of the analysis that we've done on that point.
Srdjan Stankovic
Yes.I mean we did a very detailed analysis, both evaluating the efficacy data forpatients with and without diarrhea either of the co-primary outcome measures.We also looked at the scatter plots. We looked at the responder analysis. So wedid look -- we did perform a very detailed analysis and all of them point inthe same consistent conclusion that there is no indication of any bias in termsof the assessment of efficacy in regard to diarrhea as adverse event. But as Isaid that question was not raised and there was no discussion on that questionat all in the meetings.
Ritu Baral
Gotit. Were those analysis -- Serge, were those analysis prespecified andsubmitted as part of the statistical analysis plan?
Srdjan Stankovic
Thoseanalysis will be part of our NDA submission. But obviously, statisticalanalysis plan is always submitted prior to unblinding the data. So there wasn't-- these analyses were not part of the statistical analysis plan because therewasn't any information or based on which you could anticipate those analysis.
Jeff Hung
Foryour collaboration with Stoke on Rett, can you just remind us of how that maybe differentiated from trofinetide and how different might the patientpopulation be than those that you could treat with trofinetide?
Srdjan Stankovic
Yes.The Stoke technology addresses about 1/3 of the patient that have -- thatdisplay genetic hypermorphism. So that's not the entirety of the population,but rather as I said, about 35% to potentially 40% of the overall population ofthe patients. And the difference in technology is that based on thisintervention, the increase in the protein is actually on the gene that is not-- that is performing suboptimally. So from that perspective, it's a completelydifferent approach than what in general is approached with trofinetide.
Stephen Davis
Ithink just to -- maybe just to add a couple of indications there. One is withtrofinetide we have rights to North America and with Stoke collaboration ourrights are worldwide in that program. And then the short version is with theapproach that we're taking in collaboration with Stoke, there's a greaterpotential for disease modification. So potential for an even greater or moreprofound effect with that type of approach. So we're -- we think that programis a very, very nice complement to the franchise that we're building aroundtrofinetide.
MatthewNirenberg
Andthen separately, we were just curious about any physician feedback you mighthave gotten so far after the Phase III Lavender results for trofinetide and howyou're currently thinking about the market opportunity in terms of drivingdiagnosis rates. That would be really helpful.
Srdjan Stankovic
I can say that weare quite pleased with the level of enthusiasm and excitement that we areseeing with treating physicians and experts out there in regard to the data. Imean it's, to some extent, understandable, considering that so far, therehaven't been successful late-stage programs in Rett syndrome, for treatment ofsymptoms of Rett syndrome. So from that perspective, there is quite a bigexcitement not only in the medical community, in the scientific community butalso in the parents and caregivers and community.
Sobottom line, we are very enthusiastic to see the level of excitement andenthusiasm across and look forward to the NDA and approval.
Brendan Teehan
AndI just want to echo, Serge's comments. The Rett treatment community has givenus very encouraging feedback on what they've seen of the Lavender results. Butto address your question specifically, Matt, around Rett diagnosis. As with anumber of rare pediatric diseases, the pursuit of a diagnosis has increasedpretty dramatically over time. There is already a high diagnosis rate for Rett.So we have access to databases that will show us physicians and numbers ofpatients that they have that are already diagnosed with Rett. There's also beena significant increase in genetic testing in recent years. And we, as anorganization, will work diligently and are pursuing a number of avenues toeducate on MECP2 testing and then looking at potential partnerships to haveconfirmatory MECP2 testing for suspect Rett patients post launch.
JasonButler
Justwondering if you can speak to the commercial prep work, you'll be doing in Rettthis year. Obviously, I assume that the infrastructure outbuild will mainly betowards the end of the year and into next. But from a medical educationperspective, just can you walk us through the work you're going to be doing toget the market ready for the drug?
Brendan Teehan
Myhumble apologies, Jason, thanks again for the question. Yes, obviously, we'revery excited about trofinetide opportunity. And we have been preparing even asthe Lavender study was ongoing in Phase III for a favorable result. The initialwork, obviously, we want to work with the payer community to make sure thatthey're aware of the burden of illness, understand the unmet medical need andthe size of the patient population, roughly 6,000 to 9,000 patients. We alsohave developed over time strong relationships with the foundations that supportpatients, caregivers, and the health care community, which has helped us tounderstand where we're going to find our Rett patients and the volumes ofpatients that we're going to want to support.
Andthen broadly, another area that we'll focus on are our white glove supportservices to be prepared by the time of launch, to support families, not onlygetting started on trofinetide, but to have a successful clinical experience,all of the support that they need from a clinical perspective as well as priorauthorization assistance with co-pay and so on. So those are probably theprincipal areas where we'll focus as they relate to the product.
Forthe disease state, obviously, this is a tightly knit community. There's a highlevel of awareness of Rett syndrome. We will work with the community to makesure that where necessary confirmatory MECP2 tests will also be available forsuspected patients with Rett at any of their HCPs.
Events& Presentations | Acadia Pharmaceuticals Inc. (acadia-pharm.com)
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Sharere: it goes like this? Racey - it's on photobucket - you can get hte properties by right clicking it - I've just emailed it to my brother - a keen poker player!
Salty - howsabout an email update please imo!!- *Removed* this post has been removed from public view
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ShareWhat a fascinating thread reading back 3 months!
Lots of reading today!
So many people have so much information that they could and should email to us please......
[email protected]
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$12.54 |
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Mkt cap ! $1.559B | |||
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| 1 | 761 | 12.210 |
| Price($) | Vol. | No. |
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