I'd be very interested in your take once you get to it GC.
I'll listen again tomorrow, but there was one point where JP said that the PMD trial worked so much better than expected and they are targeting similar afflictions scored upon a similar measurement scale, so there's 'no reason to believe that 2591 won't do the same in those indications'. (Note: I'm paraphrasing from memory only).
Ann: 2023 Results webinar, page-32
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