Ann: 2024 Full Year Results Investor Presentation, page-18

Hi growthgauge

Nanosonics's research work on an automated endoscopic reprocessor which used nanonebulant technology to wash, disinfect, store and transport flexible endoscopes was put on the backburner not too long after 2007 when it was determined that flexible endoscopes were just too long and bulky to be placed in a trophon like chamber for high level disinfection.

Since then, the research focus from the company in relation to endoscope reprocessing has been restricted to automating and improving the cleaning components of the endoscope reprocessing task. A variety of technologies and processes relating to the endoscope cleaning process have been developed and patented by Nanosonics over the years - although I can't be certain which of those technologies/processes were actually incorporated into Coris. No doubt, this will be made apparent once Coris has been approved by the FDA.

The focus on automating and improving the endoscope cleaning task seems to be the key to overcoming patient infection risks from reprocessed endoscopes due to the frequent persistence of biofilm in small lumen crevices under current endoscope cleaning regimes. In that regard, if a medical device is not effectively cleaned of biofilm and other caked on biocontaminants, no amount of high level disinfecting will remove the risk of cross infection. As Earle Spaulding (whose categorisation of disinfection requirements for different medical devices is still used today) used to often tell his students " you can clean a medical device without disinfecting it, but you cannot disinfect a medical device without cleaning it".

zeno9