Hi .. unscientific musings , don’t listen to me .. I suspect that the investigators were interested in this biomarker because they saw positive non biomarker signs in patient and positive other biomarker indications & were …..
1. hoping that it may have reduced
2. Ensuring it had not increased
The absence of 1 may not be a problem, and may be achievable from earlier intervention. If we can deliver stasis / stability/ lack of deterioration, or a marked reduction in that rate, then we still have a blockbuster and patient has much improved treatment option.
Ann: Additional Phase 1 data suggest MPL may inhibit MND, page-125
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