In summary, we showed that certain subtypes of AML are particularly susceptible to NK cell-mediated antitumor immunity. The excellent therapeutic effect of the p53-activating drug in Rag2−/− mice suggest that combination of NK cell-based immunotherapy with p53-activating drug would be a promising treatment strategy for AML. Furthermore, our study highlighted the peculiar immune phenotypes of Rag2−/− mice that lack functional lymphocytes but have hyperactive NK cells.
https://www.nature.com/articles/s42003-023-05606-3
In summary, we showed that certain subtypes of AML are...
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