Ann: AGM Chairman's Address and Investor Presentation, page-57

Hello. I just asked Bing for a general summary for some additional discussion points. Happy reading and as ever, take Bing results as being open to corrections.

Promarker Endo and Endotest are two different methods for diagnosing endometriosis, a condition where tissue similar to the lining of the uterus grows outside the uterus, causing pain and infertility¹.Promarker Endo is a blood test that measures the levels of 11 biomarkers associated with endometriosis². It uses a machine learning algorithm to calculate a risk score for each patient, indicating the likelihood of having endometriosis². Promarker Endo claims to have a sensitivity of 92% and a specificity of 93%, meaning it can correctly identify 92% of patients with endometriosis and 93% of patients without endometriosis².Endotest is a saliva test that analyzes the expression of microRNAs, which are small molecules that regulate gene expression³. It uses next-generation sequencing and artificial intelligence to detect the presence or absence of endometriosis³. Endotest claims to have a sensitivity of over 95% and a specificity of over 95%, meaning it can correctly identify over 95% of patients with endometriosis and over 95% of patients without endometriosis³.Both tests are non-invasive and can be performed at any time of the menstrual cycle, unlike the current gold standard for diagnosing endometriosis, which is laparoscopic surgery¹. However, both tests are still under development and validation, and are not widely available yet. They also have some limitations, such as age range, medical history, and hormonal treatment, that may affect their accuracy²³. Therefore, they should not be used as the sole basis for diagnosing or ruling out endometriosis, but rather as complementary tools to support clinical judgment and imaging results.¹: [Endometriosis - Symptoms and causes - Mayo Clinic](^1^)²: [Promarker Endo - Proteomics International](^2^)³: [Endotest – Ziwig](^3^)Source: Conversation with Bing, 1/17/2024(1) Endotest Sample Collection Kit - Endoworx. https://endoworx.com.au/endotest/.(2) Endotest – Ziwig. https://ziwig.com/en/endotest/.(3) Principles of Endodontic Diagnosis - Decisions in Dentistry. https://decisionsindentistry.com/article/principles-endodontic-diagnosis/.(4) Endotest Sample Collection Kit - Endoworx. https://endoworx.com.au/endotest/.(5) Endotest – Ziwig. https://ziwig.com/en/endotest/.(6) Principles of Endodontic Diagnosis - Decisions in Dentistry. https://decisionsindentistry.com/article/principles-endodontic-diagnosis/.