Reading up on the Edwards "Resilia" valve. Looks like Dr Bart Meuris is also involved in trials of this valve.
A trial in sheep showed reduced calcification up to 72%
There hasn't been any mentions of this valve in Wayne's recent presentations.
"RESILIA tissue demonstrated, in a large pre-clinical randomized control trial conducted in juvenile sheep in mitral position, to significantly reduce tissue calcification (− 72%) and even to improve haemodynamic performance compared with the Perimount valve [16]. The RESILIA tissue also has been studied in two clinical trials to date [17, 18]. Bartus et al. found, in a single-arm observational study of 133 patients, that the RESILIA tissue provided excellent performance and safety without structural valve deterioration (SVD) [18,19,20]. In the COMMENCE trial [17, 20], 679 patients underwent Carpentier-Edwards PERIMOUNT Magna Ease™ aortic valve replacement with RESILIA™ tissue (Model 11000A) and similar excellent safety and effectiveness were demonstrated for up to 4 years without SVD. Both of these trials have included relatively young patients, with a mean age between 65 and 67 years and up to 26% of patients aged less than 60 years."
https://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-020-01155-6
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