From Cancord todayNext science Dec ¼ out todayShowing further...

From Cancord today
Next science Dec ¼ out todayShowing further signs of good sales growth during the year (details below)Still yet to hit the ball out of the park and push the company into profit zone – although very close to breakevenSo market still probably waiting for this. Independent research out of the US continues to look very good for NXS - I’ve included a couple of summaries below.Hoping this flows through to improved usage by US hospitals CheersCraig Recent research papers from USNext Science’s Xperience surgical washVs the 3 main competitors (Betadine,Irrisept,Vashe)Show clear outperformancesEffectiveness of topical adjuvants in reducing biofilm formation on orthopedic implants: an in vitro analysisCameron Kia 1, Antonio Cusano 2, James Messina 1, Lukas N Muench 3, Vivek Chadayammuri 1, Mary Beth McCarthy 1, Ezigbobiara Umejiego 1, Augustus D Mazzocca 1Affiliations expandPMID: 33529773 DOI: 10.1016/j.jse.2020.12.009AbstractBackground and hypothesis: The treatment of periprosthetic joint infection is complicated by the presence of residual biofilm, which resists eradication owing to bacterial adherence to orthopedic implants. The purpose of this study was to compare Bactisure (Zimmer Biomet, Warsaw, IN, USA), povidone-iodine (Betadine), and chlorhexidine gluconate solution (Irrisept; Irrimax, Gainesville, FL, USA) in reducing biofilm formation of Staphylococcus aureus, Staphylococcus epidermidis, and Cutibacterium acnes inoculated on cobalt-chrome, titanium, and stainless steel disks, representing metals commonly used for shoulder arthroplasty. The hypothesis was that there would be no significant difference in biofilm reduction among the 3 topical adjuvants.Methods: Strains of S aureus (ATCC 35556), S epidermidis (ATCC 35984), and C acnes (LMG 16711) were grown on cobalt-chrome, titanium, and stainless steel disks. For each strain, the disks were divided into 4 groups: (1) control, (2) povidone-iodine (Betadine), (3) chlorhexidine gluconate (Irrisept), and (4) Bactisure. Bacteria were grown on 5% sheep blood agar plates. Biofilm eradication was quantified using adenosine triphosphate bioluminescence and compared with controls 48 and 72 hours after implementation of the topical adjuvant.Results: At 72 hours after implementation of the topical adjuvant, a statistically significant reduction in colony-forming units was observed for all topical adjuvants across all tested metals, as compared with their respective control. With respect to the topical adjuvants themselves, Bactisure more consistently demonstrated the most significant reduction in colony-forming units across all bacteria when the tested medium was adjusted for, with the exception of S aureus, which showed similar results to Betadine at 72 hours.Conclusion: By use of commonly encountered topical adjuvants on S aureus-, S epidermidis-, and C acnes-inoculated disks of various implant metals, a significant reduction in biofilm production was observed. Bactisure, a recent Food and Drug Administration-approved topical adjuvant, demonstrated the overall greatest efficacy of the agents studied.