“ Cellular entry of SARS Cov - 2 depends on the extra cellular receptor ACE 2 and the serine protease transmembrane serine protease 2 both are expressed in both nasal and bronchial epithelium . Single cell RNA sequencing analysis confirms that ACE 2 is enriched in human airway epithelium.
Distinct stem/progenitor cells proliferate to regenerate the trachea intrapulmonary airways and alveoli in Covid -19 patients . Fang et al 2020.
” immunofluorescence analysis that the ACE 2 is abundantly expressed in the oral mucosa, particular in the surface epithelium cells “
Oral epithelial expression of angiotensin converting enzyme -2.: Implications for COVID-19 diagnosis and prognosis . Srinivasan et al 2020.
”SARS - Cov- 2 readily infects well differentiated proximal ( upper ) airway cells leading to viral replication and gene expression”.
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modelling and drug discovery
Mulay et al 2020.
WEHI understands !
All is good .
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