Ann: Appendix 4C - March 2019 Quarterly Report, page-13

The sp is down, probably due to the recent release of the escrowed shares. Not to worry, just look at the potential. PromarkerD could be a CDx to all of these gliflozin drugs.

Sodium-glucoseco-transporter 2 (SGLT2) inhibitors, also called gliflozin drugs, are anew class of diabetic medications indicated for the treatment of type 2diabetes. They have also been found to show cardiac benefits in patients withdiabetes, and are being studied for possible use in type 1 diabetes. They workby reducing the absorption of glucose via the kidneys so that excess glucose isexcreted through urination.

The following drugsbelong to the SGLT2 inhibitors class (trade name first, generic name inbrackets):

· Forxiga (Dapagliflozin)

· Invokana (Canagliflozin)

· Jardiance (Empagliflozin)

About Forxiga

· Trade name: Forxiga

· Generic name: Dapagliflozin

· Drug class: SGLT2 inhibitors

· Manufacturer: Bristol-Myers Squibb and AstraZeneca

About Jardiance

· Trade name: Jardiance

· Generic name: Empagliflozin

· Drug class: SGLT2 inhibitors

· Manafacturer: BoehringerIngelheim and Lilly Diabetes

About Invokana

· Trade name: Invokana

· Generic name: Canagliflozin

· Drug class: SGLT2 inhibitors

· Manufacturer: Janssen Pharmaceuticals