i agree with your sentiments about Ca. pancreas but i dont think OSL brachytherapy is the answer. Thete is very good external beam radiotherapy already available. In Perth there is Cyberknife which has pinpoint accuracy and tracks respiratory motion to minimise collateral damage. Endoscopic guided injection of silicon particles will be technically challenging. How will you accurately distribute the doose in the tumour? What about vessels (SMA/SMV)? Will the pancreatic tail be accessible? What about peripancreatic nodal or distant metastases?
You refer to Lu PSMA radiopeptide therapy in Ca prostate. This technology is more likely, in my view, to be efficacious as a systemic, low toxicity treatmentt, in combination with radiosensitising chemotherapy. Pancreatic tumours also express PSMA receptors so the answer may be staring us in the face.
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