Ann: Appendix 4E and 2022 Annual Report, page-2

Australian Centre for Oral Oncology Research & Education Significant progress has been made in oral lesion imaging by Professor Farah and his team in Perth using the ViewnVivo® device, with new cases imaged with multiple dyes and correlated with histopathology. Imaging from this group has shown a significantly strong correlation between confocal images and traditional histopathology. Advanced correlation study analysis has been undertaken for potential development of alternative molecular markers and machine learning algorithms to enhance imaging and improve diagnostic accuracy. The work undertaken by this group has generated data that has also been included in the Company’s planned submission documents for FDA clearance, and is expected to lead to high quality scientific and clinical publications of significance to researchers and clinicians in the target market of application.