Looks like it work. In Tanzis dish!
.In preliminary (unpublished) studies using this 3D neural culture model of AD, PBT2 was observed to significantly reduce levels of detergent-resistant (TBS-insoluble) phospho-tau (relative to total tau), and to significantly increase neuronal cell viability (based on LDH levels). Preliminary studies also revealed that PBT2 led to a trend toward an increase (approximately 5-fold) in the ratio of soluble/insoluble A-beta. Based on these findings, current experiments are aimed at confirming these findings and further testing the hypothesis that PBT2 prevents aggregation of Abeta into oligomers and plaques resulting in a decrease in neurofibrillary tangles and increased neuronal cell viability.
Great read that!
Looks like it work. In Tanzis dish! .In preliminary...
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