Ann: Appendix 4E and Annual Report, page-39

This is a great find @JabraD. They have demonstrated in sample of 66 pts with IIH (with a control group of 25 healthy females) that cognition is impaired in IIH (e.g., sustained attention and executive function) and that these deficits improve over a 12-month period with a reduction intracranial pressure. We also have to note that the control group is fairly small (n=25) and that the statistical power comes from the lowest group size. So, with a greater sample, they could have found deficits across multiple cognitive domains. Yes, there is a conflict of interest here with Prof. Sinclair, but the results make sense - of course these deficits are going to affect visual performance. I wonder if cognition will feature at all in their secondary or exploratory outcomes in their Phase 3 trial design.