CHM chimeric therapeutics limited

Targeting CDH17 holds great promise and there is mounting...

  1. 1,303 Posts.
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    Targeting CDH17 holds great promise and there is mounting pre-clinical evidence supporting that.

    For example, I found this article published in Frontiers of Immunology last week, "Recent Progress and Future Prespectives of Immunotherapy in Advanced Gastric Cancer", which links (61) to the article in Nature:

    https://hotcopper.com.au/data/attachments/4486/4486420-82b7dd54768b1407e4e11b8c07230697.jpg

    Reference (60) refers to a study published in January this year, "Antitumor responses in gastric cancer by targeting B7H3 via chimeric antigen receptor T cells", which sheds some light into the target B7H3:

    https://hotcopper.com.au/data/attachments/4486/4486456-737e3e2c244353120115974d265e4e7a.jpg

    [...]

    https://hotcopper.com.au/data/attachments/4486/4486461-b5ce2bad2278aef7fc80502495641534.jpg

    [...]

    https://hotcopper.com.au/data/attachments/4486/4486467-cde2abe9480f86870985036e26f14392.jpg

    [..]

    https://hotcopper.com.au/data/attachments/4486/4486481-7d3228d956ab76c5f1f8a0dbff041e95.jpg

    [...]

    https://hotcopper.com.au/data/attachments/4486/4486482-3179cd08da9210f5a55bbec7b88e581b.jpg

    Coming back to the article quoted at the beginning and one of the potential issues with the above:

    https://hotcopper.com.au/data/attachments/4486/4486527-0ba5a0f3c88ca48e8622d6b2b0ff6bf9.jpg

    That's where CHM's approach could help.

    According to the underlying patent:

    https://hotcopper.com.au/data/attachments/4486/4486541-bca531e77d232a7a587ee7b0f7be1f28.jpg
    [...]

    https://hotcopper.com.au/data/attachments/4486/4486544-ea2e1bea561a1f4a582351f84cdfc548.jpg
    https://patents.google.com/patent/WO2019210155A1/en


    Also mentioned in Nature (see ASX announcement):

    https://hotcopper.com.au/data/attachments/4486/4486560-c123c43eff0d844fdd0b4bcfeb16fc7a.jpg


    This T cell derived autologous therapy will eventually also lead us to our NK cell derived allogeneic therapy:

    https://hotcopper.com.au/data/attachments/4486/4486570-1161e4feecb6988d6a3d73eb88e36d41.jpg

    And the above only covers a small part of what CHM has to offer... for a MC of less than A$45 million.
 
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