I believe there are a few trials going on right now?
Have a look for yourself where the competition is coming from?
Monash Uni is just one, but there are many others that are looking to operate in your domain, OK Avita could lower it's price I suppose, but that may be like closing the stable door after the horse has bolted and how will all those board members be able to maintain their lucrative salaries?
Like I said they are coming, you will notice the words
cost effective or commercially affordable comes around very often.
Polymedics are the company chosen by Polynovo as their European Distributors!
Polymedics makes Suprathel.
I believe PNV chose Polymedics for a reason beyond just being a distributor?
Doesn’t Europe have a ban on any medical device that was tested on animals?
https://www.ncbi.nlm.nih.gov/pubmed/18216512Suprathel, a new skin substitute, in the management of partial-thickness burn wounds: results of a clinical study.
Schwarze H1, Küntscher M, Uhlig C, Hierlemann H, Prantl L, Ottomann C, Hartmann B.
Author information
Schwerbrandverletztenzentrum mit Plastischer Chirurgie, Berlin, Germany.
[email protected] Ann Plast Surg. 2008 Apr;60(4):415.
AbstractOBJECTIVE:
A prospective, randomized, bicentric, nonblinded, clinical study was conducted to evaluate the impact on wound healing of Suprathel in partial-thickness burn injuries. Suprathel represents an absorbable, synthetic wound dressing with properties of natural epithelium.
METHODS:
Thirty patients suffering from second-degree burn injuries were included in the study, with a mean of age 40.4 years old. Burn injuries were randomly selected, partly treated with Omiderm and partly treated with Suprathel. The first gauze change was applied the fifth day postoperatively, followed by regular wound inspection until complete reepithelization. The study focused on patient pain score, healing time, analysis of wound bed, ease of care, and treatment costs.
RESULTS:
There was no significant difference between the 2 materials tested regarding healing time and reepithelization. There was a significant lower pain score for patients treated with Suprathel (P = 0.0072).
Suprathel becomes transparent when applied, thus allowing close monitoring of wound healing. In contrast to Omiderm, Suprathel shows better attachment and adherence to wounds. During the course of healing, it detaches smoothly, without damaging the reepithelized wound surface. Moreover, it reduces the frequency of dressing changes required. Ease of care of Suprathel has been rated outstanding by patients and healthcare professionals. When interviewed, patients reported Suprathel as their treatment preference. As dressing material, Omiderm is more cost-effective than Suprathel.
CONCLUSION:
Suprathel represents a reliable epidermal skin substitute, with a good impact on wound healing and pain reduction in partial-thickness burn injuries. Although it is less cost-effective than Omiderm, the significant increase of patient comfort makes this material represent a reliable and solid treatment alternative when dealing with partial-thickness burn injuries. Further studies with this synthetic dressing on other types of wounds are warranted.
PMID: 18216512
DOI:10.1097/SAP.0b013e318056bbf6
This PDF below may be of interest to people here who are interested in PNV and its collaborations.
It is also worth remembering that PolyMedics is a privately owned company which could perhaps make it easier for a takeover? YEP that may require a cap raise LOL.
Here is page 1 of the PDF, there are 12 Pages.
Application of SUPRATHEL® in different indications
Scientific Update 01/2019
ABA 2019, Las Vegas & ISBI 2018, New Delhi
The IL-6, TNF-alpha, and TGF-ß Levels in Serum and Tissue in Children with Treated by Different Burn Dressings......
Prof. Mehmet Demircan, Dr. Kubilay Gürünlüoglu
THE REASON FOR FASTER WOUND HEALING AND LESS SCARRING IN PATIENTS TREATED WITH SUPRATHEL MAY BE THE
SIGNIFICANTLY LOWER INFLAMMATORY RESPONSE (INTERLEUKIN-6 AND TNF-Α REDUCED) AND AN INITIALLY HIGHER SERUM LEVEL OF TGF-Β
Use of polylactic membranes as a dressing for sprayed keratinocytes – retrospective review over 103 cases......
Dr. Bernd Hartmann, Dr. Herbert Haller
SUPRATHEL PROVED TO BE AN ADEQUATE DRESSING FOR SPRAYED KERATINOCYTES IN DEEP 2ND DEGREE BURNS. 91% OF
THE WOUNDS WERE HEALED WITHIN 14 DAYS
The treatment of epidermal and deep dermal wounds with polylactid based membrane and foam structures: 8 years
perspective and outlook....
Dr. Ariel Miranda, Dr. Jesus N Briseño Villanueva, Dr. Teresa Chavez Velarde
SUPRATHEL HAS BECOME A STANDARD FOR TREATING PARTIAL THICKNESS BURNS IN MEXICO. A FAVORABLE WOUND ENVIRONMENT LEADS TO FASTER HEALING AND BETTER OUTCOMES... SUPRATHEL IS IDEAL FOR THE TREATMENT OF BURN WOUNDS
Improvement in acute healing and scaring of deep dermal and partial thickness burn wounds after enzymatic debridement
by application of platelet rich fibrin (prf) – first experiences....
Dr. Alexandra Schulz, Dr. Wolfram Heitzmann, Prof. Dr. Paul Christian Fuchs, Dr. Jennifer Schiefer
SUPRATHEL IN COMBINATION WITH ENZYMATIC DEBRIDEMENT AND PLATELET RICH FIBRIN IS A PROMISING THERAPEUTIC CONCEPT FOR DEEP DERMAL BURNS
Sprayed epithelial autografts covered with polylactic templates in deep dermal burns...
Dr. Bernd Hartmann, Dr. Sander Frank, Dr. Claudia Belfekroun, Dr. Herbert Haller
SUPRATHEL SUPPORTS HEALING OF SPRAYED KERATINOCYTES IN DEEP DERMAL BURNS
The use of Suprathel in deep partial-thickness burns: long-term follow-up results of a prospective trial.....
Dr. Paul Wurzer, Dr. David Benjamin Lumenta, Dr. Janos Cambiaso Daniel, Dr. Christian Smolle, Dr. Alexandru Christian Tuca,
Dr. Raimund Winter, Dr. Michael Schintler, Dr. Lars-Peter Kamolz
SUPRATHEL CAN REPLACE AUTOLOGOUS SKIN GRAFT IN DEEP DERMAL BURNS WITH SATISFACTORY OUTCOMES
(only satisfactory?) Biochemically evaluation and comparison of the effect of different burn dressing on systematic oxidative stress in systemic
inflammatory reaction in children with thermal burn injuries......
Prof. Mehmet Demircan, Dr. Kubilay Gürünlüoglu
SUPRATHEL REDUCES THE SYSTEMIC OXIDATIVE STRESS IN PATIENTS WITH BURNS - MORE THAN SILVER PRODUCTS
But like I said there are other things happening as well-: see below
https://www.phenion-us.com/news/the-phenion-open-source-reconstructed-epidermis-goes-live-923886Mar 28, 2019
New product!
The Phenion® Open Source Reconstructed Epidermis [OS-REp] goes live!
With a new, pure epidermal equivalent Phenion takes the next step to provide innovative, biotechnologically produced 3D tissue equivalents.The
OS-REp is the cost-effective alternative for applications which do not rely on OECD-approved tissues or methods or which do not need complexe skin equivalents.
The Open Source Reconstructed Epidermis consists of primary human keratinocytes cultured under air-liquid interface conditions. All epidermal layers characteristic for native human skin are developed including a multi-layered stratum corneum. Its high xenobiotic metabolic competence is comparable to that expressed in the epidermis of the Phenion® Full-Thickness Skin Model and in human skin
https://clinicaltrials.gov/ct2/show/NCT04014400https://www.monash.edu/medicine/new...ers-make-inroads-into-skin-tissue-engineeringScientific-Update-01-2019-ABA-2019-Las-Vegas-ISBI-2018-New-Delhi.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412373/AbstractTissue engineered skin substitutes for wound healing have evolved tremendously over the last couple of years. New advances have been made toward developing skin substitutes made up of artificial and natural materials. Engineered skin substitutes are developed from acellular materials or can be synthesized from autologous, allograft, xenogenic, or synthetic sources. Each of these engineered skin substitutes has their advantages and disadvantages. However, to this date, a complete functional skin substitute is not available, and
research is continuing to develop a competent full thickness skin substitute product that can vascularize rapidly.
There is also a need to redesign the currently available substitutes to make them user friendly, commercially affordable,and viable with longer shelf life. The present review focuses on providing an overview of advances in the field of tissue engineered skin substitute development, the availability of various types, and their application
Publication 30/5/2015
https://www.liebertpub.com/doi/pdf/10.1089/biores.2015.0015IntroductionThe technique of spraying cells was proposed by Bahoric et al. with an in vitro study in which epidermal cells were sprayed on cell culture plates with a pumpaction aerosol nozzle.1 Since then, researchers have accomplished both in vivo and in vitro studies with different experimental setups and techniques.
Various types of spraying devices were used: commercially available airbrush pistols,2–4 pump heads,1,5 atomizers,6 and clinically used spray nozzles.7–9
However, systematic studies on the influence of spray processing on different cell types are
still sparse. Especially for the field of tissue engineering, spraying is a highly promising option: As necessary for epithelial or endothelial cells, thin (single) cell layers can be applied onto tissue-engineered constructs.
In vitro studies have revealed diverse results on cell behavior and survival after spraying depending on procedure and cell type.
When analyzing the influence of nozzle diameters and air pressures on fibroblast survival,
decreasing viability with increasing pressures and decreasing airbrush nozzle diameter with viabilities ranging between 37% and 94% was found.4
As described by Duncan et al., different hydrostatic, shear,and elongation stresses act on the cells and might be a reason for this variance.10
Looking at in vivo experiments and clinical studies,different models were investigated. So far, the main focus was on wound healing for burn or chronic wounds,5,7,11–13
Better epithelial coverage and histological results in a porcine (isn't that an animal?) wound closure model have beenhttps://smw.ch/article/doi/smw.2019.20079You can thank Keepsmiling for my contribution here.
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