PER percheron therapeutics limited

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Cuprum29

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07/01/25

16:28

Post #: 77305081
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Originally posted by samfiodiving: ↑

Cuprum
My tomorrows did not terminate our EAP for fun it was done pure and simple because the drug was manufactured by another company and not the ooriginal manufacturer

i am not saying this is the cause but that is what happend in our EAP for 1102/1103 the last time around so it is obviously a critical factor

i want to know when our drug even in animal studies for Lukemiea in mice has been seen to down regulate cd49d

This is the big factor for me DID IT or DID IT NOT down regulate our target as it has been shown to do in every trial it has been tested in see below

Not only human trials in MS and DMD but as i said see below

A Novel CD49d Targeting Antisense, ATL1102, Effectively Mobilizes Acute Myeloid Leukemia Cells

https://www.sciencedirect.com/science/article/pii/S0006497118507977

QUESTION TO THE BOARD

DID WE OR DIDNT WE SEE ANY CHANGE IN OUR TARGET

Expand

Originally posted by itsagas: ↑

It was explained at the AGM that the top line results only included clinical assessments of the boys.
The laboratory results eg CD49D was only available to the Board at end of January.
This is because the external laboratory company waits until all blood tests are at their site and they run all samples at an allocated time slot of their choosing.
That is why the Board haven’t made any final decision regarding the future of the drug. But in the meantime the ongoing dosing of boys has stopped as no clinical benefit was seen.
The boys are also released from the study to afford them opportunity to enroll in other trials if they wish.
In addition detailed investigations into manufacturing are occurring as is standard practice in such situations. l

All is not lost Sam
But
The Board don’t need the distraction at the moment
Remember it was CG who changed the trial to a shorter one..No Pharma wanted to touch us until results..
Where would we be if we had to cough up $120 million for the trial in Europe…( delisted)

Jg and AF got their options because they had a Partner lined up post read out.. also a great deal of fanfare organised.. post readout …
one can imagine their disappointment.

Gennadi / Moses do the right thing by other shareholders
Leave your anger and frustration at home..
we are all dealing with the Loss $$
no unwashed or Washed here
we have all lost $$$ and time ..

..

Expand

Guys,
I am not a bio guy. All I know is stuff from uni so I will leave the details to people who know better.
Basically, I believe failure can be attributed to ineptitude or bad luck instead of malice on anyone's part.
Let's see what the detailed analysis reveals and let's hope the management can do their job without distractions.

PER Price at posting: 0.9¢ Sentiment: Hold Disclosure: Held
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