"The Directors of Biotron Limited (‘Biotron’ or ‘the Company’) are pleased to advise that it is in the process of
evaluating several promising compounds for activity against coronavirus, including the new novel strain known as
2019-nCoV.
Within its proprietary small molecule compound library Biotron has over 30 compounds with good activity against
a range of coronaviruses, including human coronaviruses that cause mild, cold-like symptoms as well as the SARS
coronavirus that was responsible for the outbreak of that virus in 2003. These compounds can reduce the levels of
coronavirus by 90 - 100% in infected cell cultures. Importantly, several compounds have broad-spectrum activity
against multiple strains of coronaviruses.
In response to the recent coronavirus outbreak in China Biotron is now focused on testing a select set of these
compounds against the new 2019-nCoV. This work will be done under contract in specialist laboratories that have
access to this new virus, which has only been isolated and made available for such studies in recent days. Biotron’s
priority will be testing its compounds that have shown broad-spectrum activity against different coronaviruses.
Biotron’s core expertise lies in the design and development of drugs that target virus-encoded proteins known as
viroporins. The company’s scientists were the first to identify and publish data showing that the E protein of the
coronavirus is viroporin and a good target for antiviral drugs. While Biotron’s focus has been on its lead clinical
HIV-1 eradication and its promising preclinical Hepatitis B virus (HBV) programs, the company has continued to
progress earlier stage research on development of drugs to target respiratory infections including coronaviruses. "
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