Cytokine storm and consequent acute respiratory distress syndrome (ARDS) characterized by dysfunctional immune responses and severe pulmonary injury are the main causes of SARS-CoV-2-related death(Guan et al., 2020; Mehta et al., 2020; Zhang et al., 2020).
And sorry to keep banging on about it, but here is our old friend the 'E' protein.
Here we show that the SARS-CoV-2 envelope (2-E) protein alone is sufficient to cause acute respiratory distress syndrome (ARDS)-like damage in vitro and in vivo. Over expression of 2-E protein induced rapid pyroptosis-like cell death in various susceptible cells and robust secretion of cytokines and chemokines in macrophages.
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