It doesn’t appear that FTO is involved in the synergy between bisantrene and decitabine - at least based on the data presented in the poster. Bisantrene is a very interesting drug and not everything is about FTO.
To answer your other questions.
1. Mouse models of leukaemia are closer to human disease than solid tumours, but there are lots of variables - this is why we do human trials.
2. It is hard to directly translate dose from mice to humans, but around 50-80/m2 would be a good rough estimate. This is pretty low by human standards. Of course like everything, mice are not little humans so we are going to have to wait until we see human data on the combination to know how well it will work. Things do look about as good as you could hope for from an animal model.
- Forums
- ASX - By Stock
- RAC
- Ann: Bisantrene shows potent anticancer activity in AML models
Ann: Bisantrene shows potent anticancer activity in AML models, page-57
-
- There are more pages in this discussion • 33 more messages in this thread...
You’re viewing a single post only. To view the entire thread just sign in or Join Now (FREE)
Featured News
Add RAC (ASX) to my watchlist
(20min delay)
|
|||||
Last
$1.69 |
Change
-0.090(5.06%) |
Mkt cap ! $288.0M |
Open | High | Low | Value | Volume |
$1.78 | $1.78 | $1.63 | $449.0K | 263.5K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
2 | 2300 | $1.67 |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
$1.69 | 8176 | 1 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
2 | 2300 | 1.665 |
1 | 5180 | 1.650 |
1 | 500 | 1.635 |
5 | 19098 | 1.630 |
2 | 4461 | 1.625 |
Price($) | Vol. | No. |
---|---|---|
1.690 | 8176 | 1 |
1.720 | 1160 | 1 |
1.735 | 3313 | 1 |
1.750 | 6000 | 1 |
1.790 | 1000 | 1 |
Last trade - 16.10pm 02/10/2024 (20 minute delay) ? |
Featured News
RAC (ASX) Chart |