A lot of your questions will need to wait for the full paper being published as I don’t want to steal the thunder of Nikki’s team so I will avoid commenting on questions 1 to 3.
In regards 4 the independent conditions have been measured, but not all yet.
In answer to question 5, twice a week worked better than once a week. In humans, bisantrene is likely to be used twice in a week once every 4 weeks on a constant background of oral decitabine. The aim is to balance toxicity with anticancer efficacy. Ultimately, the exact protocol used will be up to the investigator.
Ann: Bisantrene shows potent anticancer activity in AML models, page-60
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