Studies in the clinic have demonstratedBIT225 treated isolated cells from HIV-1 infected patients show reduced HIV-1 release from CD14+ monocytesFollowing 10 days of monotherapy in HIV-1 infected patients, BIT225 can reduce viral copy numbers and inhibit replication in myeloid lineage cells (including dendritic cells)BIT225 may impact on macrophage associated immune activationBIT225 is able to cross the blood-brain barrier, with potential to treat HIV-associated neurocognitive disorder (HAND)
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