Brequinar (IC50 = 713 nM) is only 5x less potent than Bisantrene (IC50 = 143 nM) at inhibiting FTO.
So still in nanomolar range.
But it has the other problems which you mention.
Brequinar (IC50 = 713 nM) is only 5x less potent than Bisantrene...
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