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Ann: BTX 1702 Rosacea Study Approval, page-59

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dachopper

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31/03/21

15:29

Post #: 52177515
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Originally posted by triage: ↑

Hi Deadlifts - I would think safety and tolerance are exactly the primary endpoints you would expect from a Phase 1a trial. I think more to the point is what concentrations of CBD they will be testing. As some poster quite insightfully suggested the other week, the company already knows that at 5% and 10% concentrations CBD is safe and tolerable but maybe, for the benefit of the acne product as much as this product, they want to see what happens if they bump the concentration up to 15% or 20%. I can't see in this announcement what the two levels of concentration will be but I suspect that other poster was spot on.

If this trial shows that at say 20% CBD the product is safe and tolerable, even if it does not prove a clear winner when it comes to rosacea - and in no way am I saying it won't be shown to have an effect - they can use the primary endpoint success here on whatever they decide to do with the acne product's development. That, I would guess, is why they are holding off on the next step of the acne product development until they get the results of this trial.

The other point I picked up is that this is a very robustly constructed trial. I think there was some frustration that in the antimicrobial resistance trial the patients were not required to do a wash like apparently was required in other similar trials. It would have been an easy enough extra step but without it Botanix could not show how good the results were. Also, I'm not sure where the stuff up in the previous acne trial was but the US results in that trial again muddied what they could say. So, a big tick for this trial being robustly designed.

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They have allready tested it much higher, I think they said 20 or 30% in a previous trial without issues.

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Ann: BTX 1702 Rosacea Study Approval, page-59

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Coda Minerals (ASX:COD) enters rights issue to further exploration in South Australia

BCI reaches close of funding facility for salt-first part of Mardie project

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Recce eyes Indonesia for novel anti-infective as Indo-Aus ties grow stronger

Buxton projects new graphite province discovery at WA Narryer play

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Ann: BTX 1702 Rosacea Study Approval, page-59

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Actinogen Medical ramps up Alzheimer’s treatment trials, targeting fast-track global approvals

Cokal upgrades infrastructure for BBM ramp-up in Indonesia

Coda Minerals (ASX:COD) enters rights issue to further exploration in South Australia

BCI reaches close of funding facility for salt-first part of Mardie project

White Cliff jumps 24% on 'bonanza grade' copper rock chips at Rae project, Canada

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