Ann: Canine Cancer Trial Update, page-177

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Buckland

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23/03/23

21:47

Post #: 66931600
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Originally posted by adreamer: ↑

From the last announcement:

The trial allows for up to 46 dogs

On page 2 of the announcement it says 36 dogs have been treated with MPL (plus 5 more but they were removed from the trail as stated on pages 2 and 3)

Of that 36 dogs, a further 5 dogs are not being counted (Also on page 3 below the table highlights dogs NOT included) because their plasma MPLS levels were outside of the target levels (these were the very first dogs and before they understood the biphasic nature of the drug)

36 - 5 = 31 dogs

Then there were 2 new enrollments, at time of the announce, commencing the study

31 + 2 = 33 dogs

Of the 33 dogs, there are 11 dogs that are PASS
2 with Partial Response (this is extremely good)
8 with Stable disease (this is good)
1 named Bella that has not completed the bloods but we are told on page 3 is stable disease and ThePig is as happy as him in mud!

Because 26 dogs have fully completed (page 3), they can assess up to a further 20 more dogs from which to find 8 more PASS marks

26 + 20 = 46

So 8 from 20.....
However, 1 is Bella who needs to complete bloods to 100% confirm but has already been assessed as SD.

20 - Bella = 19 dogs in the remaining pool of candidate dogs
AND
8 - Bella - 7 dogs required to fill the trail target

There are 5 dogs minus Bella (4 dogs) awaiting blood work
There are 2 dogs on study at the time of update

6 dogs studies or on study but we don't know the outcome yet.

Then there is a further 13 dogs they MAY recruit if they need them to attain the PASS of 18 dogs overall out of up to 46.
The 6 dogs with the unknown outcome may contribute to the 7 dogs (plus Bella = 8) still required

Now, here is the more important point.

Regardless of if the pet dog is assessed as: Partial Response, Stable Disease or Progressive Disease, on day 28 of the trail, they are, on average, living 3 times longer than without treatment.

I think my work here is done. (but not going to bank on it)

adreamer

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If your calculations are correct then the announcement issued at 1.02pm on 20 December 2022 is incorrect.
Why would they issue a clarification stating 8 more dogs out of 18

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