Hi again Hesk. Just saw your second post. I was under the...

Hi again Hesk. Just saw your second post. I was under the impression we changed to blood bourne cancers because it seems we definately need something that can be given intravenously, and as cpps appear to start entering cells as soon as they come in contact it was decided blood would probably absorb many before they ever got near the original target of breast tumors or similar.

That was why i was a little confused on what they were first suggesting. I thought the whole point of our cpp and endosomal escape was that we could select a cpp that only enters a particular cell type, ie cancer tumor. Ideally that could be put in blood stream and could "seek out" tumors. I thought that sounded awesome and was what they were suggesting. Now seems not to be the case or why change to blood i guess?I guess the assumption must be that many human cells are similar as far as cpp is concerned and possibly not that specific? It appears cpp enters many cells within the human body weather escaping endosomes or not. I assume it is selected to be most effective in the selected cell type but its effect on similar cells cannit be discounted. I assumed this was where bioexec's comments on "sink effect" came from wrt cpp general absorption.