PYC pyc therapeutics limited

FPP An FPP is a CPP – that is, a PYC proprietary,...

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    FPP

    An FPP is a CPP – that is, a PYC proprietary, Phylomer-derived CPP. “The tractor” as ds likes to describe it.

    From the June 7 presentation, Slide 18
    New assay reveals more efficient Phylomer-derived CPPs defined as ‘FPPs’


    (KLAKLAK)2

    (KLAKKLAK)2 is the apoptotic cargo. Lack of efficient permeation dramatically lowers its efficacy. Hence the need for a serious tractor!

    From one of the references given in Slide 22 of the June 7 presentation
    - Fantin et al., Cancer Res 2005;65:6891-6900

    The mitochondriotoxic PAP domain of sequence (KLAKLAK)2 is a synthetic peptide originally developed to enhance the activity of a natural antimicrobial peptide . This class of polypeptides that preferentially permeabilizes bacterial membranes rich in anionic phospholipids have also been shown to affect mitochondrial function in vitro. The PAP selected for this study cannot efficiently permeate across eukaryotic plasma membranes and consequently exhibits low mammalian cell cytotoxicity. However, when coupled to selective targeting domains, (KLAKLAK)2 is internalized by cells, induces mitochondrial damage, and triggers apoptosis.

    http://cancerres.aacrjournals.org/content/65/15/6891.full
 
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