FPP
An FPP is a CPP – that is, a PYC proprietary, Phylomer-derived CPP. “The tractor” as ds likes to describe it.
From the June 7 presentation, Slide 18
New assay reveals more efficient Phylomer-derived CPPs defined as ‘FPPs’
(KLAKLAK)2
(KLAKKLAK)2 is the apoptotic cargo. Lack of efficient permeation dramatically lowers its efficacy. Hence the need for a serious tractor!
From one of the references given in Slide 22 of the June 7 presentation
- Fantin et al., Cancer Res 2005;65:6891-6900
The mitochondriotoxic PAP domain of sequence (KLAKLAK)2 is a synthetic peptide originally developed to enhance the activity of a natural antimicrobial peptide . This class of polypeptides that preferentially permeabilizes bacterial membranes rich in anionic phospholipids have also been shown to affect mitochondrial function in vitro. The PAP selected for this study cannot efficiently permeate across eukaryotic plasma membranes and consequently exhibits low mammalian cell cytotoxicity. However, when coupled to selective targeting domains, (KLAKLAK)2 is internalized by cells, induces mitochondrial damage, and triggers apoptosis.
http://cancerres.aacrjournals.org/content/65/15/6891.full
- Forums
- ASX - By Stock
- Ann: Cell-Penetrating Phylomers Improve Delivery of Drugs-PYC.AX
PYC
pyc therapeutics limited
Add to My Watchlist
0.40%
!
$1.27

FPP An FPP is a CPP – that is, a PYC proprietary,...
Featured News
Add to My Watchlist
What is My Watchlist?
A personalised tool to help users track selected stocks. Delivering real-time notifications on price updates, announcements, and performance stats on each to help make informed investment decisions.
|
|||||
Last
$1.27 |
Change
0.005(0.40%) |
Mkt cap ! $740.7M |
Open | High | Low | Value | Volume |
$1.27 | $1.29 | $1.27 | $406.0K | 319.3K |
Buyers (Bids)
No. | Vol. | Price($) |
---|---|---|
1 | 13987 | $1.27 |
Sellers (Offers)
Price($) | Vol. | No. |
---|---|---|
$1.29 | 1380 | 1 |
View Market Depth
No. | Vol. | Price($) |
---|---|---|
1 | 13987 | 1.265 |
1 | 15000 | 1.260 |
1 | 12000 | 1.255 |
1 | 4000 | 1.225 |
1 | 20000 | 1.220 |
Price($) | Vol. | No. |
---|---|---|
1.290 | 25630 | 2 |
1.295 | 24500 | 1 |
1.300 | 59168 | 4 |
1.325 | 9001 | 1 |
1.330 | 20000 | 2 |
Last trade - 16.10pm 27/06/2025 (20 minute delay) ? |
Featured News
PYC (ASX) Chart |
The Watchlist
PAR
PARADIGM BIOPHARMACEUTICALS LIMITED..
Paul Rennie, MD & Founder
Paul Rennie
MD & Founder
SPONSORED BY The Market Online