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Sorry the auto-correction had mangled the most important word...

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Medicine Man

204 Posts.

1722

20/10/22

23:13

Post #: 64310130
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Originally posted by Medicine Man: ↑

You are right @hottod Autism Spectrum Disorder (ASD) could be caused by a monogenic or heterogenic neurodevelopmental disorder.

ASD is a common condition, and the number of children diagnosed with ASD has been increasing rapidly in the past few decades. In 2021, the prevalence of the disorder in the United States is estimated at 1 in 44 children.

In most individuals with ASD caused by rare gene mutations, the mutations occur in only a single gene. SHANK3 in particular is the target for PYC's 3rd pipeline drug to treat Phelan-McDermid Syndrome.

Genes associated with ASD are:

ADNP
ANK2 ARID1B ASH1L CHD2 CHD8 CTNND2 DYRK1A GRIN2B KCNQ3 MECP2 POGZ PTEN RELN SHANK3 SYNGAP1 UBE3A
ASXL3
CACNA1H CNTN4 CNTNAP2 DSCAM EIF4E **RB3 KATNAL2 KCNQ5 KDM5A KDM5B MYT1L NLGN1 NLGN3 NRXN1 PTCHD1 RPL10 SCN2A SHANK2 SYN1 SYN2 TBR1 TMLHE

PYC's stealthy patent filing DID NOT mention which gene it is applying to. One simplistic assumption is those 4 patents would refer to 4 different genes. Now it is not hard to image that PYC is working on 3 other monogenic disorders yet to be announced! Leveraging on PYC's efficient and low toxicity drug delivery platform and Professor Sue Fletcher's proven ability to engineer RNA cargos, the team would certainly deliver dugs for the druggable diseases in the next 2-3 years.

Reference:
https://medlineplus.gov/genetics/condition/autism-spectrum-disorder/#inheritance

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Sorry the auto-correction had mangled the most important word "unduggable"

it should read
...the team would certainly deliver dugs for the undruggable diseases in the next 2-3 years.
PYC Price at posting: 6.2¢ Sentiment: Buy Disclosure: Held
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