Ann: Chair's Address and CEO Presentation, page-7

1. just a reminder
   16/9/20 from hottod
   
   Avecho
   
   The following information describing AVE’s TPM injectables products has been condensed from two presentations, which were released in December 2019 and June this year.
   
   TPM®/Daptomycin
   • Daptomycin is supplied as a lyophilized powder for reconstitution
   • TPM increases daptomycin solubility, allowing reconstitution in < 5 minutes to significantly increase workflow efficiency in the hospital
   • Daptomycin shelf-life stability increased to 24 hours at RT, and 72 hours in fridge.
   • Longer stability also enables larger, multi-use vials and provides commercial supply chain advantage
   
   TPM®/Propofol
   • TPM creates a transparent and thermodynamically stable microemulsion
   • No egg or soy based excipients, no risk of anaphylaxis, and reduced risk for bacterial growth
   • Clear formulation (better presentation) allows QC and confidence during infusion / mixture – less chance of product recall
   • Simple manufacture method; COGS projected to be cheaper than standard propofol emulsion
   • TPM® would significantly reduce the risk and expense of the supply chain for propofol
   • Could grow the overall propofol market, which has suffered from manufacturing issues and resulting product shortages
   
   TPM®/Vitamin K
   • TPM dissolves the Vitamin K in a stable, colloidal vesicle system
   • TPM formulations of Vitamin K developed which are: - free of problematic excipients (Cremaphor, Polysorbate 80, Lecithin) - stable for 2yrs - suitable for dosing paediatric (2mg/ml) and adult (10mg/ml) patients
   • There are no known allergens in the product, and no anticipated safety concerns.
   
   TPM®/Tacrolimus
   • TPM/Tacrolimus formulations made without Cremaphor (known adverse excipient)
   • TPM solubilizes tacrolimus during dilution prior to infusion
   
   TPM®/Melphalan
   • Melpahan is a water insoluble powdered (lyophilized) drug dissolved prior to use
   • There are no commercially available liquid formulations that would reduce handling prior to administration.
   • Liquid TPM/melphalan formulations successfully created
   
   TPM®/Clopidogrel
   • Clopidogrel is a powder given as an oral tablet for stroke.
   • An immediate, injectable alternative dosage format would be advantageous for stroke patients, but clopidogrel is insoluble at the typical pH range of IV injections (pH 3-10).
   • Liquid TPM/clopidogrel formulations suitable for injection successfully created