Ann: Change in substantial holding-BLT.AX, page-19

J8, I did not hear the comments made but there was a paper published recently which stated that the use of CRISPR to treat HIV has been seen to produce aggressive mutations. This was because CRISPR is not 100% accurate and the small degree of inaccuracy is all the virus needs to mutate. In another paper, RNAi was seen a better alternative (at present) because multiple targets can be addressed in the one treatment.

I think that this is good news for Calimmune as it has the potential to give them a longer lead time before newer technologies take over.