Ann: Change of Director's Interest Notice, page-4

We have had the Ceo James Campbell / Director Melanie / and Board Member Gavin Shepherd all purchase reasonable amounts of shares in PTX recently, l am not a doctor or Scientist or a Pharmacist or a Financial expert but l am very confident they would be accumulating because of the potential in regard to the commercialisation of PTX 100. I have been very patient over the last 5 years as many other shareholders have also been, but let's not be confused if the Phase 2 results are similar to the Phase 1 results we are on track to becoming one of the most sought-after Companies in Oncology Worldwide. Just remembering our Phase 2 patients that are in the current active cohort are starting with substantially less prior treatments for example less Chemo sessions, l look forward to Prof Miles Princes patient results during the year.