Daaaaamn. I was just having the same thoughts. And there they...

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Bran

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148

09/03/21

23:37

Post #: 51643772
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Originally posted by Mason14: ↑

Well, this is exactly the kind of information that I like to walk out of work with. Forgive me for being late to the party with some commentary on this announcement; I have a sore head from some birthday celebrations.

Dr. T has discussed the important points of the announcement and that is great, but what hasn't been discussed yet is likely the most significant part of this finding.

Looking at papers released around certain cell lines, we can find more amazing data.

There are two studies that have linked FTO overexpression with the MCF-7 breast cancer cells (1,2).

*HCC1937 means normal breast cancer cells.

Also, the studies suggest that FTO knockdown significantly inhibited breast cancer growth, colony formation, and survival

Also, that FTO inhibition can decrease breast cancer cells energy production.

Could this be an indication that the efficacy bisantrene in resistant MCF-7 breast cancer cell lines is due to the recent discovery as a potent FTO inhibitor?

It is my belief that the efficacy we have seen in these cell lines is the first preclinical data we have of bisantrene inhibiting FTO in breast cancer cell lines known to overexpress FTO relative to normal breast cells. I cannot stress enough the importance of this finding. I believe that these findings suggest that bisantrene was inhibiting FTO in these cell lines leading to increased cell death as well as reducing energy production, which in turn decreased tumor growth, metastasis, and colony formation.

Make up your own mind.

All IMO - DYOR.

1. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437932/
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5452952/

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Daaaaamn. I was just having the same thoughts. And there they are, outlined far more eloquently than my speculation. If this was planned by RAC, then they are way ahead of us with FTO... Knowing Dr Tillets grasp of the science, this isn’t an accident. Holy sheet. I’ve got my house in RAC now, and it’s dawning on me that it isn’t enough. I think we are going to start seeing 5, 6, 7 dollars like they are cents. RAC really is in a Race before big pharma realise what they are doing, or we are going to be undersold.

RAC Price at posting: $3.90 Sentiment: Buy Disclosure: Held
41 Upvote

2 Great analysis

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