Yes this is the major point. Previously we had data that Bisantrene performed just as well as doxorubicin (but was safer to the heart), we now have evidence that Bisantrene works better than doxorubicin in drug resistant patients (i.e. late stage metastatic patients). It is much easier to get a drug approved (and sell) that both works better and is safer.
Ann: Compelling Preclinical Breast Cancer Results, page-53
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