I mat be wrong but i thought serum stability may be better, toxicity about same but the bonus initially was proprietry inhibitors more potent see below.
From september 15 update
" two of these Phylomer cargoes demonstrate superior activity to the gold
standard MYC inhibitor (OmoMYC) for the ability to kill cancer cells"
Phylogica recently announced the results of an independently performed
animal model of disease that demonstrated the ability of its Cell Penetrating
Phylomers (CPPs) to deliver a drug cargo called OmoMYC inside cells to
effectively inhibit MYC. Phylogica is now pleased to announce that:
• It has identified multiple Phylomer peptide cargoes that are able to
inhibit activity of MYC when delivered as drugs inside cancer cells;
• two of these Phylomer cargoes demonstrate superior activity to the gold
standard MYC inhibitor (OmoMYC) for the ability to kill cancer cells;
• it will evaluate an expanded set of potential candidates before selecting
a lead cargo to assess for drug like properties when conjugated to its
lead CPP and delivered in an animal model of cancer.
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I mat be wrong but i thought serum stability may be better,...
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