Ann: Confirmation of Preliminary COVID-19 Results, page-237

kpax,

Could it be because Covid 19 might induce anti-body dependent enhancement (ADE), (a process known to happen with the Dengue virus) as suggested in this paper as a possiblity https://onlinelibrary.wiley.com/doi/full/10.1002/jmv.26009?af=R? (thanks dryasachip)

(As I understand it) ADE works basically like this: because Covid 19 "looks" a lot like other very common but relatively harmless covid viruses that many people have already developed neutralising antibodies for, it tricks the already "trained" memory b cells to produce the wrong types of covid antibodies instead of waiting for the "naive" b cells to be "instructed" to make a perfectly fitting antibody for covid 19. The result is the wrong antibodies are produced in number, and only stick loosely to virus (so called "cross reactivity"), and when the virus is absorbed by a monocyte (a type of white blood cell), the improperly fitting neutralizing antibody comes loose from the virus which allows the virus to reactivate inside the monocyte, turning the monocyte into a covid 19 factory. From there the hijacked monocytes start producing the IL 6 cytokine signalling protein en masse producing a "cytokine storm" that creates the dangerous inflammatory immune response while telling the body (via the mTOR system) to down regulate the production of killer T-cells at the very time they are most needed to destroy hijacked cells, allowing covid 19 to be replicated like crazy.

If this is the case, then only a certain limited amount of MPL is needed to direct the mTOR system into somehow suppressing the memory b cells from producing the incorrect covid anti-bodies, thereby preventing covid 19 using these anti-bodies to hijack the monocytes for their own purposes.

Or to put it another way, I think it might be because MPL works on the mTOR system, not on the virus itself, as we saw in the cancer trial, so only a certain amount is needed to flick mTOR regulatory switches in our cells and thereby frustrate Covid 19's ADE style hijacking of the immune system.

Does that make sense?