Part of the article in The Aus:Noxopharm’s Graham Kelly - the cancer researcher who saved his own life
Graham Kelly will never forget the year 2014. Some of the top cancer specialists in Australia told him that the treatments on his prostate cancer had failed and that the cancer had spread around his body.
He might live another month, maybe two. To make matters worse, if that was possible, earlier results from the cancer treatment he had developed, using material obtained from plant legumes, had been disappointing.
But since that disappointment, and despite his illness, Kelly had been frantically checking his research and now believed there was nothing wrong with his drug. Rather the fault was in the way it had been administered.
He then made a decision that has the potential to be a fateful global moment in late stage cancer treatment. He tested his conclusions by injecting himself with the drug using his revised delivery methods. He had nothing to lose. It worked -- and he is still alive. A miracle.
It has taken another seven years but after further refinement the Australian drug (now called Veyonda) and its delivery method are now about to start phase two clinical trials.
Australia has rarely been at the global forefront of cancer drugs and the listed company Kelly formed to develop and test his discoveries, Noxopharm, is not claiming a cure but rather an extension of life for critically ill prostate, lung, breast and other late stage cancer patients.
It’s rare to find such a dramatic story among listed companies so it is worth recording the story of Veyonda, Noxopharm and its executive chairman.
Back in the early 1970s Kelly was working in Sydney University’s department of transplant surgery, with particular emphasis on kidneys. A large number of those receiving the early transplants later suffered skin cancers as a result of the anti-rejection drugs.
Kelly did a lot of work to determine what was actually causing these cancers, which led him to link into the research being conducted on why people in Japan and parts of China suffered much lower cancer rates than those in western societies.
At the time the fashionable answer was that meat eating in western societies was the reason for the difference, but that turned out to be wrong. What prevented the Japanese and many Chinese from getting cancer was the large amount of legumes and the so-called “isoflavones” that dominated their diet.
Kelly discovered that in the 1960s massive plantings of a special clover substantially increased dietary isoflavones in sheep, which reduced their birthrates. For Kelly the lesson from the sheep experience was that isoflavones from legumes were powerful materials that could alter bodily functions.
He developed a theory that isoflavones from legumes were actually metabolised within the body to produce novel chemicals. These chemicals possessed important hormone-like functions, which made important contributions to human health.
Excited, he left academia and founded the company, Norvet Ltd, which listed on the ASX in 1994 - the same day as CSL. It later changed its name to Novogen.
It was that company that had been hit with the disappointing results.
In 2015 Kelly established private biotechnology company Noxopharm Pty Ltd and floated it a year later.
Phase one trials have been successful and now the next step, the much larger phase two trials, are about to start and the company has the cash to complete them.
The trials will be conducted in Australia, US, France and Hungary at 15 sites. The international contract research organisation, Parexel will oversee the study, which will involve approximately 100 patients with cancers that have failed standard treatment options.
The main focus will be late-stage prostate cancer where, as happened with Kelly, the cancer has spread from the prostate to other parts of the body. Kelly has expanded the trial to include late-stage breast and lung cancer patients.
If the trial is successful (and despite the “Kelly trial” there are no certainties) in theory Noxopharm could raise the large sums required to conduct a stage three trial.
But if Veyonda and its delivery methods are successful in the treatment of cancers that move out of their origins it will impact a very large number of people. Veyonda would become a major global drug requiring extensive distribution systems.
Accordingly, it is almost certain that Noxopharm will link with a pharmaceutical giant if Veyonda goes to phase three. Australia’s only company with the resources able to conduct phase three trials is CSL, but a late-stage cancer treatment is way out of its ambit
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