The big players are not here yet because they are smart enough...

The big players are not here yet because they are smart enough to use their money making more money elsewhere.
When PTX has some actual deals underway so that realistic financial analysis can show the profit potential, they will turn up.
IMO that may be as far as 2-3 years away - but I am convinced it will happen.
It could happen earlier with either PTX 200 or PTX 100 but I doubt it will be for any licensing collaboration for OmniCAR because they like PTX will have to await trial results. I doubt the cell enhancement tech will pay big bucks soon but I will be happy if it does.

Meanwhile, in the absence of meaningful information the SP will probably cycle between highs of news and lows of world market problems.
This is a boring phase that agitates the short term holders expecting 10x SP growth in a few months or that it didn't happen last year as the cheerleaders promoted. .
Unfortunately, about 50% of PTX shareholders have less than 100,000 shares and it is they, not the larger holders, that exit at the first sign of market negativity.

The patient will be rewarded, hopefully sooner rather than later - but it will happen. I certainly will be there when it happens and buy more when the big players turn up.