Is this consistent with "legacy effect"? the patients who received DMX in this period received PBO previously, so how would they show some persistence of effect? Or am I missing something here. The press release is unfortunately not perticularly clear. Doesnt the fact that the "second baseline" value for the PBO group in fig 2 is close to zero suggest there is no legacy effect, given that these patients are the ones who were on DMX 6 weeks previously? Let me know if I've miss read this.
i never thought the "legacy effect" stuff sounded perticularly robust.
the study design looks like a way of getting a second bite at the Apple with a single patient cohort, whilst boosting recruitment as all patients know they will receive study drug.
this reads as positive to me and shows a greater treatment effect than the first study period, which is readily attributable to the variability of disease and small patient population.
question would then be, was period 2 fortunate to show a larger treatment effect, or was period 1 unfortunate to show a small one. Perhaps a bit of both?
all in all, encouraging result
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