Ann: Drug Delivery Greater Than 100% More Effective - Amended, page-2

Change is this text inserted by way of explanation underneath the results bar-chart. Didn't see anything else...

"Detailed explanation of Figure 2: The chart depicts a group of 9 mice (left hand bar) treated with a CPP-PMO whose retina was harvested and the exon-skipping in two cellular layers (the Retinal Pigment Eipthelium (RPE) and choroid) was measured. The right hand bar represents a group of 3 mice treated with the same CPP-PMO at the same dose and whose retina was harvested to assess exon-skipping in a single cellular layer (the RPE). The exon-skipping in our target cellular layer for the lead Retinitis Pigmentosa program (the RPE) is 2.5 fold higher than the combined RPE and choroid indicating greater effectiveness of the drug in our target cellular layer. This result is statistically significant with an unpaired t-test, two tailed, of p=0.0082. The result complements earlier announcements comparing PYC’s CPPs to competitive delivery technologies (see ASX announcement of 23 July 2019) and also alternative chemistries for the backbone of the antisense oligonucleotide drug cargo (see ASX announcement of 3 September 2019)."