Hi Lastly,
Apologies missed your post from a few days ago. Interesting discussion.
Gliobastoma is a difficult one to treat.
Monepantel is a mTOR inhibitor mainly concentrated on Complex 1. The latest studies show that the problem with Glioblastoma is to do with mTOR inhibitors C2.
So their thinking is a dual mTOR inhibitor such as Torin-2 in combination with a mtorC1 inhibitors may benefit these patients.
This study in 2016 gives us an idea.
" mTOR inhibition in glioblastoma: Requiem for a dream "
Its been mentioned many times in the past that Monepantel can be a stand alone drug or used as a combination drug .
It is worth noting that patients that received Everolimus had a lower progression free survival than the control arm.
Why , the drug synergies between the two caused increased toxicities.
Anyway it didn't work.
Monepantel is a different drug to Everolimus.
The "new owners" will investigate that given time.
Kpax
Hi Lastly,Apologies missed your post from a few days ago....
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