from the last call they were considering optimal patient stratification with a view to capturing age range where the gradient of disease progression is the highest to demonstrate efficacy.
aligning the 12 month phase 1 time interval vs natural history studies of disease participants who have marked regression - we’ll be able to infer that the drug works by halting if not reversing disease progression that would otherwise incurred.
it’s very smart actually, goes to show the level of thinning around the complexity to maximise strategic value outcomes with fixed shareholder resources
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