Ann: First ADOA Patient Dosed in Clinical Trial, page-5

Change from baseline for Best-corrected visual acuity (BCVA) letter score using

Early Treatment of Diabetic Retinopathy Study (ETDRS)

Change from baseline for Low contrast visual acuity (LCVA)

Change from baseline for Perimetry

Change from baseline for posterior eye healthy by fundus examination, using ultrawide funduscopy

Change from baseline for colour vision by Hardy Rand Rittler test

Change from baseline for contrast sensitivity by Pelli Robson Chart

Change from baseline for visual field sensitivity by Static Perimetry

Change from baseline for Multifocal Visual Evoked Potential (mfVEP)

Change from baseline for retinal nerve fiber layer (RNFL) and Ganglion Cell Layer (GCL) thickness by Spectral domain optical coherence tomography (SD-OCT)

Change from baseline for mitochondrial function test by flavoprotein fluorescence (FPF) analyzer (Ocumet Beacon)

Change from baseline for Detection of Apoptosis in Retinal Cells (DARC)