My question to the MND webinar.
Riluzole blocks release of glutamate through reduced synapse formation and subsequent electrical activity.
It has a low grade autophagic component in Beclin 1 and LC3AII.
Monepantel disrupts P13K via the mTOR pathway.
Both P13K and Beclin 1 are responsible for considered autophagy in the human body.
If one was to companion Riluzole and Monepantel together the synergy of P13K and Beclin 1 it may possibly recruit to the mitochondria and golgi apparatus to form an isolated membrane in phagophore through recycling the endosome.
Ref : Oncotarget 2016 Zhan et al
Ref : Impaired autophagy in motor neurones: A final common mechanism of injury and death. Gonzales et al 2018.
Ann: First Patient Dosed in MND Phase 1/2 Trial, page-123
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