Hi Densey,Great study and explanation.You would have noticed...

Hi Densey,

Great study and explanation.

You would have noticed this quote in said study.

Mandrioli et al. noted that rapamycin combined with riluzole, a glutamate blocker, can clear the cytoplasmic TDP-43 aggregates through induced autophagy.

The key to this pathway is MEK 5 , mTOR inhibitors reduce MEK5 expression which suppresses TDP-43 toxicity via the mTOR-independent activation of the autophagy-lysosome pathway. ( It's complex to explain and all I can say is that both drugs are synergising the excess protein removal)

MND possibly can be controlled by combining Riluzole and Monepantel.

The science stacks up , we may make a huge difference.

This forum goes way above any other and it's hard for me to keep up with what's happening.

Chill out good people, my best advise. No point in getting anxiety over the Company unless you want to be anxious.

Nearly every day I pick up another good scientific vibe that complements my jig saw.