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Ann: Further Positive Results From Adult Clinical Study-RAP.AX, page-3

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    ResApp Announces Further Positive Results from
    Adult Clinical Study
    - Achieved high levels of accuracy (91%-100%) for distinguishing adult patients
    with URTI, COPD, asthma or pneumonia from subjects with no discernible
    respiratory disease
    - Demonstrated differential diagnosis of asthma versus COPD, pneumonia
    versus asthma and pneumonia versus COPD at 88%-94% accuracy
    - Correctly detected lower respiratory tract disease in 84% of adult patients
    initially diagnosed as clear by experienced clinicians using stethoscopes
    - Finalised clinical protocol and confirmed three leading US hospitals for US
    paediatric study, SMARTCOUGH-C
    Perth, Western Australia, 3 October 2016 -- ResApp Health Limited (ASX: RAP) today
    announced further positive results from its adult clinical study underway at Joondalup
    Health Campus (JHC) and the Wesley Hospital. This additional set of preliminary
    results, prepared by the team led by Associate Professor Udantha Abeyratne at The
    University of Queensland, again demonstrates high levels of sensitivity, specificity and
    accuracy on an expanded adult dataset.
    ResApp’s cough sound-based algorithms achieved between 91% and 100% accuracy
    for distinguishing adult patients with chronic obstructive pulmonary disease (COPD),
    asthma or pneumonia from subjects with no discernible respiratory disease. In
    addition, the new analysis demonstrated accuracy of 100% for distinguishing patients
    with an upper respiratory tract infection (URTI) from the no respiratory disease group
    (not previously reported). The differential diagnosis of asthma versus COPD,
    pneumonia versus asthma and pneumonia versus COPD (not previously reported) was
    achieved at an accuracy in the range of 88% and 94%. The complete set of results,
    including sensitivity and specificity are given in the table below.
    As was found in the paediatric study, the algorithms were able to correctly detect lower
    respiratory tract disease in 84% of adult patients who were initially diagnosed as clear
    by experienced clinicians using stethoscopes but were finally diagnosed as having a
    lower respiratory tract disease after additional clinical testing.
    “We are pleased to again report high levels of accuracy in a significantly larger dataset,
    which continues to build our clinical evidence base as we progress towards FDA
    submission,” said Tony Keating, CEO and Managing Director of ResApp. “It is also
    excellent to note that once again our algorithms outperformed experienced clinicians
    by correctly detecting lower respiratory tract infection in patients initially diagnosed
    as clear.”
    As with previous analyses, the performance of the algorithm was evaluated using the
    method of leave-one-out cross-validation against the final clinical diagnosis. ResApp
    notes that these results are preliminary and may change as the clinical study
    progresses. Recruitment of adult patients continues at JHC and the Wesley Hospital.
    ResApp’s US paediatric clinical study is also progressing well. SMARTCOUGH-C is a
    prospective, multi-site, double-blind study that will evaluate the efficacy of the
    ResAppDx software application in the diagnosis of childhood pneumonia and other
    respiratory conditions from cough sounds. Three leading US hospitals are now
    confirmed as study sites, with enrolment to take place at multiple locations within each
    hospital. The SMARTCOUGH-C clinical study protocol has been finalised and the study
    will begin following approval by each site’s institutional review board, which is
    expected within two to six weeks.

    more follows
    Last edited by Ben2010: 03/10/16
 
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