re: Ann: Further strong progress in CAVATAK p... Was curious what the expected survival rate was without treatment and how it compared with other drugs. 2nd question is answered below
VLA... is reaching milestones at a Phase 2 clinical trial of its CAVATAK anti-cancer drug in the treatment of late stage melanoma patients.
The Phase 2 trial at 11 U.S. sites is to investigate safety and efficacy of intra-tumoral CAVATAK injection in 54 patients with late stage malignant melanoma.
The primary endpoint of the study was to have 10 from 54 evaluable patients reporting immune-related Progression Free Survival at 6 months, which was achieved in September after only 30 evaluable patients, representing an irPFS rate of 33%.
Another key performance measure is the one-year survival following initiation of treatment with CAVATAK. Currently, 16 patients were evaluable by this measure with 9 alive at the 1 year endpoint, a success rate of 56%.
To put that into perspective, the mean one-year overall survival rate based on a review of 42 Phase 2 melanoma trials in patients treated with a variety of agents is 25.5%.
Viralytic's aim is to commence a randomised Phase 2 trial in melanoma patients in the late 2014. Strong recent recruitment rates indicate final patient enrolment by the end of this year.
THe perspective is is reaching milestones at a Phase 2 clinical trial of its CAVATAK anti-cancer drug in the treatment of late stage melanoma patients.
The Phase 2 trial at 11 U.S. sites is to investigate safety and efficacy of intra-tumoral CAVATAK injection in 54 patients with late stage malignant melanoma.
The primary endpoint of the study was to have 10 from 54 evaluable patients reporting immune-related Progression Free Survival at 6 months, which was achieved in September after only 30 evaluable patients, representing an irPFS rate of 33%.
Another key performance measure is the one-year survival following initiation of treatment with CAVATAK. Currently, 16 patients were evaluable by this measure with 9 alive at the 1 year endpoint, a success rate of 56%.
To put that into perspective, the mean one-year overall survival rate based on a review of 42 Phase 2 melanoma trials in patients treated with a variety of agents is 25.5%.
Viralytic's aim is to commence a randomised Phase 2 trial in melanoma patients in the late 2014. Strong recent recruitment rates indicate final patient enrolment by the end of this year.
Have never understood the MC of VLA. One of my favourite companies (which I have done really badly out of to date). Maybe one day.
ALl the best
KMS
VLA Price at posting:
35.2¢ Sentiment: Hold Disclosure: Held
