Ann: Half Yearly Report and Accounts, page-75

FOX News on the Colorado's murder case involving Accutane, Dr Marc Siegel puts it this way:

http://video.foxnews.com/v/5742126034001/?#sp=show-clips

"Can aggressive behaviour be linked to Accutane? Yes...[....].....A huge public service message we can do today...[...]...I think this drug is prescribed too quickly, too easily and you should look for alternative first"

So BTX1503 is not just more effective (as shown by the recent clinical study) that the two most widely used (in the USA) Epiduo and Aczone (with combined annual sales of $1b) but is going to disrupt a market ripe for a safe alternative to isotretinoin, the drug of 'last resort' against acne.